LrgpV1, Main, Exploration, bibRecord, 000095

A simple methodology for predicting the performances of hyaluronic acid purification by diafiltration

Identifieur interne : 000095 ( Main/Exploration ); précédent : 000094; suivant : 000096

A simple methodology for predicting the performances of hyaluronic acid purification by diafiltration

Auteurs : Nadia Oueslati [France] ; Pierrick Leblanc [France] ; Alice Bodin [France] ; Christelle Harscoat-Schiavo [France] ; Emmanuel Rondags [France] ; Stéphane Meunier ; Ivan Marc [France] ; Romain Kapel [France]

Source :

Journal of Membrane Science [ 0376-7388 ] ; 2015-09.

RBID : Hal:hal-01266254

Abstract

The performances of hyaluronic acid (HA) purification (yield, purity, permeate How rate and productivity) in a semi synthetic medium composed of salts, proteins/peptides by diafiltration through a 100 kDa PES membrane were studied over 10 diavolumes (DV). The HA purity went from 3% to almost 100% with a yield in the retentate close to 100% at the end of the process. The permeate flow rate showed a peculiar trend due to the influence of charged microsolutes. DF mass balance applied to three groups of solutes (HA, peptides/proteins and charged microsolutes) allowed a good prediction of HA yield and purity in the course of DF. An equation of the permeate flux based on limit flux equation, correlations between mass transfer coefficient mineral concentration and mineral mass balance was proposed to predict the process productivity. Eventually, a methodology based on these equations was proposed to predict HA yield, purify and productivity. The methodology was validated with an actual Streptococcus zooepidemicus broth. Differences between calculations and experimental performances in term of yield, purify and productivity never exceeded 10%.

Url:

https://hal.univ-lorraine.fr/hal-01266254

DOI: 10.1016/j.memsci.2015.04.024

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000057
to stream Hal, to step Curation: 000057
to stream Hal, to step Checkpoint: 000086
to stream Main, to step Merge: 000094
to stream Main, to step Curation: 000095

Le document en format XML

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<idno type="DOI">10.1016/j.memsci.2015.04.024</idno>
<series><title level="j">Journal of Membrane Science</title>
<idno type="ISSN">0376-7388</idno>
<imprint><date type="datePub">2015-09</date>
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<front><div type="abstract" xml:lang="en">The performances of hyaluronic acid (HA) purification (yield, purity, permeate How rate and productivity) in a semi synthetic medium composed of salts, proteins/peptides by diafiltration through a 100 kDa PES membrane were studied over 10 diavolumes (DV). The HA purity went from 3% to almost 100% with a yield in the retentate close to 100% at the end of the process. The permeate flow rate showed a peculiar trend due to the influence of charged microsolutes. DF mass balance applied to three groups of solutes (HA, peptides/proteins and charged microsolutes) allowed a good prediction of HA yield and purity in the course of DF. An equation of the permeate flux based on limit flux equation, correlations between mass transfer coefficient mineral concentration and mineral mass balance was proposed to predict the process productivity. Eventually, a methodology based on these equations was proposed to predict HA yield, purify and productivity. The methodology was validated with an actual Streptococcus zooepidemicus broth. Differences between calculations and experimental performances in term of yield, purify and productivity never exceeded 10%.</div>
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A simple methodology for predicting the performances of hyaluronic acid purification by diafiltration

A simple methodology for predicting the performances of hyaluronic acid purification by diafiltration

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